13 Modern Gene Therapies: Are You Ready to Break the Boundaries of Medicine?

Gene therapy is the process of creating a gene, usually a carbon copy of the original, in a laboratory in order to introduce it to the human body to cure or prevent a specific illness. Some of the new genes are a mutation or a combination of one or more genes.

Each year, new gene therapies are discovered and put to the test before introducing them to patients who can use them to recover from a number of diseases and ailments. Scientists, researchers, chemists, and doctors work long hours to come up with new therapies in gene therapies and mutation that will help hundreds of thousands of individuals live longer and healthier lives.

For more information, go to poseida.com today. In the meantime, here are 13 modern therapies that are breaking medical boundaries:

1. Instiladrin® (nadofaragene firadenovec/Sny3; rAd-IFN/Syn3)

This gene therapy is indicated for BCG (Bacillus Camette-Guérin) which is an unresponsive non-muscle invasive bladder cancer (NMIBC).

The new modified gene will take hold of nearby cells containing the tumor and pollutes and activates the translation and transcription of these genes. They are antiproliferative, immune-modulating, antiviral and antitumor.

2. Nexagon

This gene therapy is indicated for the persistent epithelial defects (PED) which do not respond favorably to the standard care treatment currently indicated for these types of defects.

This is a natural, unmodified gene that regulates, downward, the gap in hemichannel protein Cx43 (Connexin43). This gel is placed under the contact lens, or on the amniotic membrane to ensure the gene therapy makes contact with the diseased cornea.

3. OXB-301 (TroVax®; MVA-5T4)

This gene therapy is indicated for colorectal and ovarian cancers. The active ingredient is made up of an MVA (modified vaccinia virus Ankara). It is intended to destroy the cells containing cancer and at the same time stimulate the immune system.

4. RT-100 (AC6 Gene Transfer)

This particular gene treatment is designed for heart failure and reduced ejection fraction (HFrEF). HfrEF affects the left side of the heart, this side doesn’t pump any blood out to the body due to insufficient squeezing of the ventricle.

It is injected directly into the arteries during a cardiac catheterization procedure. This gene therapy is able to enter cells but cannot reproduce itself.

5.  Toca 511 (vocimagene amiretrorepvec) and Toca FC

This gene therapy is indicated to help a number of Cancers including melanoma, recently diagnosed high-grade preclinical glioma, colorectal Cancer, phase I breast Cancer, lung cancer, and renal cell cancer along with metastatic solid tumors.

This injectable is two-part immunotherapy for Cancer. The Toca FC is constructed as an extended-release oral medication.

6. VB-111 (ofranergene obadenovec)

This is a gene therapy used in phase III Ovarian Cancer that is recurrent platinum-resistant and other solid tumors. This is one of the therapies that target the anticancer biologic cells as a blockade to the tumor growth rather than eradicating it once it is formed.

7. VM202

This DNA-based medication is designed to help with diabetic peripheral neuropathy as well as non-healing chronic ischemic ulcers on the feet from diabetes. Other indications include acute myocardial infarction, or heart attack and amyotrophic lateral sclerosis (ALS).

ALS is a disease that attacks only certain types of cells in the spinal cord and the brain. These cells are crucial to keeping the muscles in the body moving. Some of the early signs of this illness include slurred speech, muscle twitching, and muscle weakness.

8. Zolgensma® (formerly AVXS-101)

This therapy is specifically designed for SMA (spinal muscular atrophy) and contains an adeno-associated virus 9, which is nonreplicating. This AAV9 capsule is used to administer a functional copy of the SMN gene directly into the nucleus of the cells in the patient. This medication is given to help the cell’s production of the protein SMN to a tolerable level.

9. OTL-103 (formerly GSK2696275)

This therapy is for WAS or Wiskott Aldrich Syndrome. WAS patients have the reduced ability to form blood clots due to abnormal immune deficiency in their system. Their platelets are decreased in size and number of cell fragments used for clotting purposes.

Collected from the bone marrow, the transduced lentiviral vector encoding or the mobilized peripheral blood, this is a genetically modified hematopoietic autologous stem cell.   

10. NSR-REP1

This is for the treatment of Choroideremia, a progressive loss of vision mostly in males. The beginning of the condition has been often the onset of night blindness and can occur in early childhood.

This gene therapy contains a recombinant human complementary DNA or cDNA that can be found in the eye under the REP1. This is a surgically injected sub-retinal style treatment. 

11. LYS-SAF302

For the treatment of Sanfilippo Type A Syndrome or Mucopolysaccharidosis IIIA (MPS IIIA). This syndrome appears when the body needs to break down the enzymes Hepara Sulfate (HS) and they are defective or absent altogether.

This gene therapy contains a healthy copy of the SGSH or N-sulfoglucosamine sulfohydrolase and is administered, through an injection, directly into the brain. This is to stimulate the production of the missing or insufficient enzyme. The goal is to halt or slow down the progression of the illness.

12. Lenti-D

Cerebral Adrenoleukodystrophy or CALD is the most severe form of Adrenoleukodystrophy or ALD. It mostly affects those with X chromosomes, and therefore is mostly found in boys. It is considered as the breakdown of the myelin or protective stealth covering cells. These cells are responsible for muscle control and thinking.

This therapy uses the patient’s own stem cells as a transplant to modify the functional copy of the ABCD1 gene. This gene will result in the production of adrenoleukodystrophy proteins. 

13. Axalimogene filolisbac (AXAL; ADXS11-001) and ADXS-DUAL 

This gene therapy is indicated for the treatment of Metastatic Cervical Cancer in women. The immunotherapy is targeted from a platform of technology using live attenuated Listeria Monocytoenes or Lm. This is a beginner gene to secrete antigen and adjunct proteins. This is the second-generation of axalimogene filolisbac.   

If you have any of these illnesses or diseases, talk to your doctor about gene therapy. There may be a trail or a new therapy available through your health care provider that is newer and maybe looking for patients for testing.

“If you are unsure if you have a health condition, consider an initial round of blood tests. HealthLabs.com is taking the next steps into more readily accessible lab testing for patients. With fast, private, and affordable lab testing, you are able to monitor your health on your own terms.”

Go to Source
Author: Ella Maclin

Nutrisystem Before and After Blog – A Weight Loss Story (Laura)

Nutrisystem Before and After Blog – A Weight Loss Inspiring Story


Laura (My Nutrisystem Success Story): Today, I made a decision to embark on the Nutrisystem diet plan. Before I actually start I intend to take a photo of myself in my existing form. Believe me, at 240 pounds I have far more weight on my body than I should have. I have placed on 100 extra pounds and in spite of disliking to take a photo of myself, I am going to do so. I am dressed in different clothes, which is an added large and short size. By the end of my Nutrisystem diet plan journey, I wish to be able to suit a tool sized swimwear. I anticipate my quest to take between 6 as well as 9 months.

I am taking a full-size photo of my front. I am likewise taking a picture of my butts as well as the tummy. Just so I recognize exactly what I looked like when I weighted all those 240 extra pounds. My legs require a bunch of work and the same choose my stomach. The reality is that every part of my body needs a great deal of job.

Nutrisystem Before and After Blog: (Photo)

Nutrisystem Before and After

Because I am one hundred pounds heavier than I was, I think my immediate objective is to lose those one hundred pounds. I am embarking on my trip right before my birthday as well as my wedding anniversary. Though it has actually taken me 3 years to put on all these added pounds, which implies that somehow I have been putting on thirty pounds a year. I assume the factor for the weight gain is taking drugs and also inadequate of sufficient workout.

NutriSystem, Inc.
This is day one of my trip and I am absolutely excited. I will be doing this weekly. I have my uncertainties regarding the Nutrisystem due to the fact that I have actually encountered several complaints about it. Anyhow I am placing myself available as well as though this is very frightening and also it is additionally not something that I really wish to do, I go to my worse and I really need to do something regarding my problem. I am going to describe my trip from an independent perspective.


I go to the end of my 4th week and also I will certainly be finishing my 5th week tomorrow. I am as assured visiting tell you how much weight I have lost as well as it is very impressive considering I have not really exercised all that much. Let’s talk about my dimensions now. My dimensions were 48 busts, 47 and also a half midsection, hips were 52 inches and my upper legs remain at 29 and also my arms were 14 inches.
Now, after using Nutrisystem my bust is 40 and also my waist is 38, my hips are 49 and also a half from fifty-two. My thighs continue to be the same but my arms are a bit thinner at 13. My waist began at virtually 255. Currently, it is 229.6 and also it just took four weeks to lose quite a great deal of weight.


I have taken a lot more images of myself and also I am looking much slimmer. All the bulges are gone though my legs are still the same however I not have fat hanging around. I am still as well heavy to put on a two-piece and I do have to do some more exercising. However, I feel that a big distinction has been made. I enjoy every little thing regarding myself currently. I attempt brand-new points and also I have actually maintained my diet plan the very same. Today, I am leaving to purchase some more Nutrisystem with using Nutrisystem Coupon Codes and offers which help me a lot with the price.

NutriSystem, Inc.


Look out Some More Success Stories: Before – After Examples

1) ARYA FARZIN LOSES 200 POUNDS – A NUTRISYSTEM SUCCESS STORY


2) ERICA LOSE 110 POUNDS – A NUTRISYSTEM SUCCESS STORY

Meals That Keep You Satisfied with Effective Weight Loss


Well Balanced Nutrition
Follow a meal strategy that’s high in healthy protein as well as fiber, as well as includes low-glycemic– clever– carbohydrates that help keep blood sugar level secure and reduce yearnings.
Regular Meals
Keep pleased as well as strong consuming every 2-3 hours. And also, mix in your preferred fresh foods throughout the day with assistance from our Grocery Guide.
Selection You Love
Select from over 150 great-tasting and healthy foods, including hassle-free ready-to-go alternatives and also our very popular icy foods.
Perfect Portions
Skip the checking and also the gauging! All our foods are portioned just right for weight loss– so you’ll drop weight without the job.

Right here’s a peek at just what a day of losing weight with Nutrisystem could resemble:

Breakfast
Nutrisystem Cinnamon Roll
Mid-Morning Snack
Low-fat string as well as carrot sticks
Lunch
Nutrisystem Broccoli Cheese Melt
Mid-day Snack
Low-fat yogurt with fresh blueberries
Supper
Nutrisystem Spinach Stuffed Shells
Treat
Nutrisystem Delicious Chocolate Brownie Sundae
NutriSystem, Inc.


Go to Source
Author: Unknown

3 Reformer Pilates studios you need to try

Anyone else noticed that reformer Pilates studios are popping up about the place more frequently than babies in your Facebook feed recently? Don’t get me wrong, I L O V E reformer, but it can be hard to know which studios are the real deal, and which you’d be better off steering clear of. Well never fear, today I bring you three Reformer Pilates studios in the Eastern Suburbs of Sydney that you need to try.

VIVE ACTIVE // Double Bay
If you’ve ever thought that Pilates was too low-energy for you, this is the studio to get into. VIVE ACTIVE has just opened in Double Bay (they have another studio in Brookvale for you Northern Beaches peeps) and their classes are filling up so fast I couldn’t get in last weekend! Think high energy Pilates with epic beats, seriously passionate trainers, and choreography that’s designed to get you the results you crave. Oh and I almost forgot the mirrored ceilings, which may sound a little rent-by-the-hour motel, but are actually ahh-mazing and very helpful for helping with form throughout the class. A beautifully designed studio and gorgeous, well-stocked change rooms are a given for the area.

What else? VIVE ACTIVE run VIVE After Dark, a free monthly wellness seminar that focuses on topics like meditation, nutrition and gut health.

Fluidform // Waterloo and Clovelly
I like to think of Fluidform as Pilates the way Joseph Pilates intended it to be. I started at the Waterloo studio when i found out I was pregnant with Alfie, and I don’t think I’ve ever had an instructor who understands the human body like Fluidform founder Kirstin King. They run group classes, but (in my opinion) the real value is in their ‘studio equipment classes’; small group sessions (maximum of four in Waterloo and three in Clovelly) that are more intimate, allowing the instructor to individualise your session for you. At Fluidform, movements are energetic and effective, but always controlled. Think full body strengthening and conditioning, helping your muscles to grow longer and leaner.

What else? Fluidform at Home is an online program that includes access to a workout library with new workouts added each month, monthly live chat with Kirsten, monthly live stream from an in-studio class and more.

One Hot Yoga // Potts Point
My love for reformer Pilates first surfaced at One Hot Yoga, about two years ago. Sure I’d dabbled before, but this was that early days of romance, can’t-get-enough-of-you, miss-you-when-you’re-gone kind of love. If you’re looking for lots of class options, experienced instructors and a beautiful studio, then this is the place for you. Class sizes are on the large side which can make it more difficult to keep on top of form, but the instructors are all friendly, so don’t be afraid to put up your hand to ask for help! And If you want something a little more personalised, they’ve recently introduced ‘studio Pilates sessions’ (which look similar to Fluidform’s offering) but I’ve never tried them so can’t comment on what they’re like!

What else? Well yoga, duh. One Hot Yoga offers a ‘One Hot Everything’ membership that gives you access to all reformer and mat Pilates group classes, plus all yoga classes.

The post 3 Reformer Pilates studios you need to try appeared first on Lazy Girl Fitness.

Go to Source
Author: LazyGirlFitness

6 ways you might be sabotaging your workouts

You’re working out on the reg, but for some reason still not seeing the results you want. Well that doesn’t seem fair, does it?

Here’s a few of the most common ways you might be sabotaging your workouts, along with some simple fixes. Recognise any of them? Yah, me too .

Always taking the most advanced option
I was in a Reformer Pilates class the other day and the instructor was giving us spring/difficulty options. Now as you know, I’ve only recently got back into the swing of exercise, so let’s just say that choosing the most difficult option would not have been a smart choice. I chose it anyway. The problem, as I was soon reminded, is that when you choose an option that’s too much of a stretch for you, you risk not going to be able to do the exercise properly. At best, this decreases the likelihood of getting results, and at worst, increases your risk of injury. Yes, I did sheepishly reduce my spring load.
The fix? Stop letting your pride get in the way, and work to a level where you can keep good form and control.

Not doing something you enjoy
I firmly believe that the best form of exercise is the exercise that you’ll actually do. Let’s be realistic; if you *hate* the gym there’s no way you’re going to keep showing up week after week. If you spend almost every moment of that yoga class wishing it was over (oh pick me, pick me!) then you’re probably better off choosing something else.
The fix? Search and ye shall find! Get out and try a bunch of different classes. Or grab your mates and head to the park, the pool, the running track. Download a workout app. Or trawl my Lazy Girl Fitness workout section. There are so many options out there, you’re bound to find something you enjoy.

Skipping the warm up
Yes yes it’s a squeeze to fit in a workout on your lunch break, I know. But spending a few minutes getting your body moving can help to get that oxygen flowing to your muscles a little faster, reduce your risk of injury and help you mentally prepare for what’s ahead.
The fix? Look it depends on the workout, but I suggest trying something simple like fast feet, side lunges or walk outs, followed by working through some of the exercises in your workout at a slow, controlled pace. Once you’re feeling warmer, try something a little high intensity, such as high knees or shuttle runs, and you’ll be ready to go!

You set unrealistic goals… or no goals at all
We all need goals to keep us motivated. Without them, you might show up, but chances are you’ll just be going through the motions. And on the flip side, if your goal is so far outside the realms of possibility that it’s unhealthy, you’ll get de-motivated pretty quickly and things will grind to a halt.
The fix: Choose a goal that is aspirational, but attainable. Then choose some mini goals that will help you get to the big goal. Measure your progress, and reward yourself when you reach a goal.

Not eating well
Running a marathon on one of the ‘2’ days of your 5:2 diet really isn’t a good idea. Likewise an intense HIIT session on a stomach full of fish and chips probably isn’t going to help you get the most out of your workout. Extreme examples, sure, but the moral is the same: if you want to make the most of your workouts, make sure you fuel your body well.
The fix? Keep your diet full of real foods – the less packaged, the better! And when it comes to pre and post-workout fuel, it will depend on when you’re working out and what sort of workout you’re doing. There’s no one-size-fits-all approach, so take a little time to figure out what works best for you and your body.

Too many high intensity workouts
God I used to be so bad at this. I was definitely in the ‘more is more’ camp, when it comes to working out… the harder and more often, the better! But here’s a newsflash younger-Jess: your body needs rest days. Without rest days, your body doesn’t actually have time to repair and re-build, which means all that hard work is going to waste!
The fix? Factor in a couple of days off each week. Use these days to get out for a nice walk, do some mindfulness, or try a gentle stretch session at home.

Make sense Team? Excellent. Now stop sabotaging your workouts, and go forth and conquer those goals!

xx

The post 6 ways you might be sabotaging your workouts appeared first on Lazy Girl Fitness.

Go to Source
Author: LazyGirlFitness

The 20 minute workout that you can do anywhere

20-minute workoutDon’t judge me, but I’ve been known to show up late to a social occasion (ok… or not show up at all) to ensure I didn’t miss my daily exercise, whether it be Pilates, a run or a quick 20 minute workout. Yep exercise and fitness has always been a priority for me… or at least that was the case until Alfie was born. As I mentioned in this post, I expected to return to exercise a few weeks after giving birth. Oh bless me and my naivety. And then when my body finally was keen, my mind still wasn’t ready to get back on the horse (or Reformer, as it were).

Anyway, my point is that there will always be times in your life when exercise takes a back seat, whether that’s because you’ve had a baby, got too much going on at work, a hectic social calendar, or, heaven forbid, you just need a break.  And that’s ok. But when you do feel like getting back into it, there are a few ways to get yourself back on track, starting with making a plan that’s easy to stick to.

This 20 minute workout should be part of that plan. It’s designed to be done at home without weights, but you can challenge yourself by using dumbbells (or even dry goods from the pantry!) if you like.

The workout

Circuit 1:
2 sets | 45 seconds per exercise | 30 seconds rest between sets 

Hip raises
Push ups
Squat hold
High knees
Reverse crunches

Circuit 2:
2 sets | 45 seconds per exercise | 30 seconds rest between sets 

Reverse lunges
Plank
Squats
Bicycle
Step ups (use a stable chair or low table)

Time-based workouts are my go-to when I’m busy or just feeling unmotivated. They’re easier to plan my life around, plus I find it easily to mentally prepare when I know exactly how long I’ll be working out for!

Hope you enjoy this one Team, it’s good to be back.

The post The 20 minute workout that you can do anywhere appeared first on Lazy Girl Fitness.

Go to Source
Author: LazyGirlFitness

Are We Rinsing With Mouthwash Long Enough?

Commercial mouthwashes are used for various purposes including getting rid of bad breath, plaque, gingivitis, etc. The American Dental Association provides a very detailed write-up on mouthwash. You may be able to get a similar benefit from a saltwater and hydrogen peroxide solutions. Many dentists state that you only need to brush and floss to support a healthy mouth.

What I have always wondered though is, assuming there is some benefit from using mouthwash, am I getting any benefit from them? The reason I question this is because the recommended rinse duration on most mouthwashes range from 30 seconds to one minute. I think I rinse for maybe 20 seconds at best. Do you rinse for one minute?

There are tons of mouthwashes out there so it can be a challenge to pick the right one for you. I found the following information for various brands of mouthwash:

Mouthwash Brand Rinse Duration (seconds) Alcohol Free? Ratings
Ranker Faveable Bestlisto Tenbestreview Bestseekers
Listerine 30 No 1 1 4.5 6
Crest 30 to 60 Yes 7 4 8 8 5
Scope 30 No 2 2
Colgate-Palmolive 30 Yes 3 3 4
Oral-B 30 No 4 4
Biotene 30 Yes 6 2 6 6 2
Cepacol 30 No 9 7
ACT 30 Yes 5 3.5 5 6.5 1
Sensodyne 60 Yes 8 9
Dr Katz 30 Yes 10
Corsodyl 60 Yes 11 10
Tantum Verde 30 No 12
BreathRx 30 Yes 13 9
Daily Rinse 60 Yes 14
Dentyl PH 30 Yes 15
Sarakan 20 Yes 16
Astring-O-Sol 20 No 17
Lavoris 30 No 18
Rembrandt 60 Yes 19 4
Gengigel 60 to 120 Yes 20
Oral Essentials 60 Yes 5 8
TheraBreath 30 Yes 3 11 10
CloSYS 60 Yes 5 3
Jason Natural 20 to 30 Yes 1
PerioBrite 30 to 60 Yes 7
SmartMouth 30 Yes 9
Tom’s of Maine 60 Yes 11

Based on the above, you may not be getting the full effectiveness of the mouthwash you are using if you are not rinsing for the prescribed about of time. I guess we have to tough it out folks and increase our mouthwash rinsing time . Good luck with that!

Sedona Red Rock Spring Break

Sedona Red Rock

Sedona, AZ is one of the most scenic locations in the United States and Spring is the best time to be there. Thus, it stands to reason that I would want to spend my Sons’ Spring Break there. Sedona Red Rock is at its most glorious state at that time. Also the weather is perfect for hiking and enjoying the outdoors. It’s the outdoors that’s Sedona’s strong point. It’s also the busiest time of year there so if you are planning on going in Spring you need to plan.

This was my third trip to Sedona. The first one was in October for the Sedona “Jazz on the Rocks Festival”. Fall is the next best time to visit Sedona since the weather can be similar to the Spring.

My second trip was in August just because that was the only time I could go that year. Though the weather in the summer is more moderate than Phoenix it is still hot. This time of year you need to get your hiking on in the mornings or late afternoons.

This trip we flew into Phoenix just list most people heading to Sedona from out of nearby states and made the two-hour drive to Sedona. We arrived in Sedona in time to check-in and check out “A Taste of Provence” which was a French festival held in the on site Tlaquepaque Arts and Crafts Village. The festival took place from 4pm to 8pm and included three outstanding free bands, a master glass worker, painting demonstrations, artwork to buy, and delicious French wines and food.

We stayed at the Los Abrigados Resort and Spa which is a timeshare resort in which I own a week at the Stonehouse property. The Historic Stone House is the most unique unit at this resort. It is a separate house across from the Main pool. It is the Schnebly’s (founder’s of Sedona) original home. It has been restored and updated to today’s standards.

The house has two master bedroom suites with spa tubs. The larger master has a huge spa tub and a separate setting room with library, flat screen TV and wetbar. It also has a huge Great Room with a working stone fireplace (wood provided free!). In addition, the unit has a full kitchen, patio, gas barbecue grill, washer & dryer and skylights galore!

You can rent a week at the Los Abrigados Stonehouse from me on the VRBO website. Just remember that I only have one week per year and it is next available in 2018.

The star of this place is the Sedona Red Rock. Continue reading “Sedona Red Rock Spring Break”